The molecular mechanisms of stress responses in stem cells and during cancer progression have always been my main area of interest and fascination. Over the past 15 years I have worked on several different aspects of this incredibly broad field. During my PhD training at the FIRC Institute of Molecular Oncology (IFOM) in Milan I investigated the molecular mechanisms by which activated oncogenes induce DNA damage and cellular senescence. I then moved to United States for a postdoctoral training at the NYU School of Medicine to perform research aimed at understanding the epigenetic and transcriptional regulation of stem cell identify. I am currently a Group Leader at the San Raffaele Telethon Institute for Gene Therapy in Milan. My lab studies the biological impact of gene editing procedures on ex-vivo manipulated hematopoietic stem cells for gene therapy applications and regenerative medicine.